ATryn
| Product Specs | Description |
|---|---|
| Manufacturer Name | rEVO Biologics |
| Indications | ATryn is a recombinant antithrombin indicated for the prevention of perioperative and peripartum thromboembolic events in hereditary antithrombin deficient patients. |
| Contraindications | Do not use in patients with known hypersensitivity to goat and goat milk proteins. |
| Manufacturing Methods | Recombinant human antithrombin produced through recombinant DNA technology using genetically engineered goats. DNA sequence directs the antithrombin expression into goat’s milk. |
| Viral Safety Process | Tangential Flow Filtration, Affinity Chromatography, Nanofiltration Ion Exchange Chromatography, Hydrophobic Interaction Chromatography, Heat Treatment. Log10 reductions range from greater than or equal to greater than or equal to 20.0 log. |
| Route of Administration | May be administered intravenously via sterile syringe or via an infusion bag |
| Product Half-Life | 50 IU/kg: 11.6 (84.7) hours 100 IU/kg: 17.7 (60.9) hours |
| Storage Requirements/Shelf Life |
|
| Available Formulations | 525 IU/3.2 mL 1750 IU/10 mL |